Protein Details: Store-operated calcium entry-associated regulatory factor
Protein ID
ICDB_Pro_0131
Protein Name
Store-operated calcium entry-associated regulatory factor
Gene Name
saraf; tmem66
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Length
319 amino acids
AlphaFoldDB
AF-F7C1E2-F1-model_v4.pdb
Function
Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling; promotes a slow inactivation of STIM (stim1 or stim2)-dependent SOCE activity (By similarity).
Sequence
MVEVANMWSLLLLPLLALLQIPGAWCWNHQERVLLRDIQAITLYADRYTNARRSAPVPQLKCIGGSAGCHTMVPQVVQCHNRGWDGFDVQWECKVDMDNSYRFGKVEVSCEGFDYPEDPYVLRGSCGLEYTLELTEEGRKRSQDGYRSGGFGSGYFQSNSNSWDTKTNGSSAIVLIVIVIIAYGVYKLFLSGPSVQEHPRPDEYGYDFQSQTRASAPPPPGFKSDFTDPHLCKIFGASKSFSSGYGTSHSNQGPGFWTGLGTGGVLGYLFGNRRAQPYQAPYFNTWTGPSNSDSMHQNYRPPQSSGVRTASGFGGTKRR
PDB Structures
Ligand Binding
Binding Site
Disease
Location
DOI ID
10.1126/science.1183670